Strategies for an HIV vaccine
نویسندگان
چکیده
The development of an HIV vaccine poses an unprecedented challenge to the scientific community. The inexorable spread of HIV worldwide and the devastating clinical consequences of AIDS can only be contained by an effective vaccine. Yet, almost two decades after the first demonstration of HIV and its etiologic role in AIDS, this vaccine still is a goal, not a reality. In this Perspective, I consider the unique problems for vaccine development posed by the biology of HIV infection, and I summarize recent advances in our understanding of the immune control of HIV and the implications of these advances for vaccine development. After reviewing the sobering history of failed traditional vaccine strategies, I discuss the rationale for vaccines with novel designs and their experimental successes to date.
منابع مشابه
Immune Response to Standard Hepatitis B Vaccination in HIV-Infected Patients
Background: Due to their similar routes of transmission, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infection occurs considerably. HBV infection progresses more rapidly in HIV-infected patients. Therefore, HBV vaccination of all non-immune HIV infected patients is recommended. On the other hand, HIV-infected subjects have suboptimal responses to HBV vaccine. In this study...
متن کاملA Shot at Dendritic Cell-Based Vaccine Strategy against HIV-1
Introduction: Despite considerable efforts to control AIDS pandemic, it is still one of the significant infectious concerns worldwide. The advance in medical research has led to the development of highly active antiretroviral therapy with a considerable effect to suppress the disease. However, an effective vaccine capable of eradication the HIV pandemic is not available yet. Failure to develop ...
متن کاملprevalence of Mycobacterium tuberculosis in patients infected with HIV by microscopical and molecular methods
Background:In some countries, one of the first and most common manifestations of HIV positive patients is tuberculosis (TB). HIV positive people are prone to other infections such as tuberculosis due to immune deficiency and reduced CD4+ cell count. Although increasing access to antiretroviral therapy has led to a reduction in HIV-related opportunistic infections and mortality, the simultaneous...
متن کاملAn HIV-1 Mini Vaccine Induced Long-lived Cellular and Humoral Immune Responses
Memory formation is the most important aspect of a vaccine which can guarantee long-lasting immunity and protection. The main aim of the present study was to evaluate the memory immune responses after immunization with a mini vaccine. Mice were immunized with human immunodeficiency virus-1 P24-Nef fusion peptide and then cellular and humoral immune responses were evaluated. In order to determin...
متن کاملPolyvalent vaccine approaches to combat HIV‐1 diversity
A key unresolved challenge for developing an effective HIV-1 vaccine is the discovery of strategies to elicit immune responses that are able to cross-protect against a significant fraction of the diverse viruses that are circulating worldwide. Here, we summarize some of the immunological implications of HIV-1 diversity, and outline the rationale behind several polyvalent vaccine design strategi...
متن کامل